The Architectural Turn in Depression Why Network Topology Will...

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2026-09-10 05:33:54 - Translate

The Architectural Turn in Depression Why Network Topology Will Redefine CNS Strategy

By Denis Katz, MD, MHAFounder, Salience Clinical For decades, psychiatry has framed major depressive disorder (MDD) as a disorder of chemistry, an imbalance of serotonin, norepinephrine, or dopamine. That model produced meaningful therapeutic advances, yet it has not consistently delivered durable remission for a substantial proportion of patients. Roughly one-third remain treatment resistant,...

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